Thomas Lissek

Profile Thomas Lissek

Scientist, Physician

Short Bio
I'm a scientist and physician. Previously, I have conducted research in molecular neurobiology, biophysics and synthetic biology and have held fellowships from the German Research Foundation and the Leo Eloesser Foundation. I studied medicine at the Ruprecht Karl University of Heidelberg, Germany and the Ludwig Maximilian University of Munich, Germany.

I'm interested in developing technologies to improve human health and in theoretical biology.

Leveraging biological adaptation mechanisms to enhance human organism function
In mammals including humans, adaptive transcription is a central mechanism to connect environmental stimulation to organism remodeling. I am decoding the internal logic of this ubiquitous molecular program to enable new approaches in medicine and human performance enhancement.
Lissek, Preprint, 2022

Reverse engineering natural genomic longevity programs
Certain environmental stimuli, such as exercise, intermittent fasting and cognitive stimulation, can extend health- and lifespans in humans and other animals. I have reverse engineered the underlying molecular programs to inform novel life extension approaches.
Lissek, Advanced Biology, 2022

Engineering the brain
I'm currently devising ways to engineer the brain by creating synthetic neural circuits. This might allow new ways to study the brain and ameliorate brain disorders.
Lissek, Preprint, 2022

Neural substrates of conscioussness
As an undergraduate student, I have leveraged two-photon calcium imaging in living mice to dissect the neural underpinnings of conscioussness. We found that neural networks become more synchronized under anesthesia and that, surprisingly, cortical neurons become more responsive to sensory stimulation.
Lissek et al, Front Cell Neurosc, 2016. Press: MedicalXpress.

Molecular algorithms in reward learning and addiction
For my doctoral work, I have decoded a new molecular algorithm centering on the transcription factor Npas4 that controls how strongly mice react to cocaine.
Lissek et al, EMBO Rep, 2021. Press: MedicalXpress.

Neurogenomic computing
I proposed a new concept for biological computation termed neurogenomic computing. It leverages natural and synthetic interfaces between neuronal membranes and the genome.
Lissek, Front. Bioeng. Biotechnol., 2017